Title page for ETD etd-09072005-093949

Type of Document Master's Thesis
Author Campbell, Jason
Author's Email Address jncgrasshopper@hotmail.com
URN etd-09072005-093949
Title The Importance of Size and Shape in Imprinted Polymers
Degree Master of Science (M.S.)
Department Chemistry
Advisory Committee
Advisor Name Title
David Spivak Committee Chair
Gudrin Schmidt Committee Member
Paul Russo Committee Member
Robin McCarley Committee Member
  • influenza virus
  • imprinted polymers
  • chiral amines
Date of Defense 2005-08-08
Availability unrestricted
The existence of shape selectivity in non-covalent molecularly imprinted polymers has been proven using molecular probes. A series of amines varying with different structural motifs and secondary amines with different sized side chains were imprinted, and binding evaluated by HPLC for each amine on polymers imprinted with similar amines. Trends in the binding relationships revealed two major contributions of cavity structure on selectivity afforded by molecularly imprinted polymers (MIPs). First, sterics play a dominant role in cases where a molecules structure is too big too fit into an imprinted site formed from a smaller template molecule. Second, molecular structures that are equal to or smaller than those of the template molecule are selected by maximizing Van der Waals interactions within the MIP binding site.
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