Type of Document	Master's Thesis
Author	Campbell, Jason
Author's Email Address	jncgrasshopper@hotmail.com
URN	etd-09072005-093949
Title	The Importance of Size and Shape in Imprinted Polymers
Degree	Master of Science (M.S.)
Department	Chemistry
Advisory Committee	Advisor Name Title David Spivak Committee Chair Gudrin Schmidt Committee Member Paul Russo Committee Member Robin McCarley Committee Member
Keywords	influenza virus imprinted polymers chiral amines
Date of Defense	2005-08-08
Availability	unrestricted
Abstract The existence of shape selectivity in non-covalent molecularly imprinted polymers has been proven using molecular probes. A series of amines varying with different structural motifs and secondary amines with different sized side chains were imprinted, and binding evaluated by HPLC for each amine on polymers imprinted with similar amines. Trends in the binding relationships revealed two major contributions of cavity structure on selectivity afforded by molecularly imprinted polymers (MIPs). First, sterics play a dominant role in cases where a molecules structure is too big too fit into an imprinted site formed from a smaller template molecule. Second, molecular structures that are equal to or smaller than those of the template molecule are selected by maximizing Van der Waals interactions within the MIP binding site.
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