Title page for ETD etd-0801102-165734

Type of Document Dissertation
Author He, Ming
Author's Email Address minghe@lsu.edu
URN etd-0801102-165734
Title Synthesis and Study of New Materials for the Visual Detection of Biomolecules
Degree Doctor of Philosophy (Ph.D.)
Department Chemistry
Advisory Committee
Advisor Name Title
Robert M. Strongin Committee Chair
Paul Russo Committee Member
Robert Hammer Committee Member
William Crowe Committee Member
James Catallo Dean's Representative
  • visual detection
  • biomolecules
Date of Defense 2002-06-20
Availability unrestricted
The visual determination of saccharides has been of interest for well over a century. Sugars are a relatively challenging class of compounds to analyze. They exhibit great structural similarity as well as transparency in the visible region. The sensing of specific saccharides could aid the monitoring of disease or industrial fermentation products. Herein I present new methods allowing for simple and rapid visual detection of sialic acid, fructose and a homologous series of prototypical neutral oligosaccharides, the linear maltodextrins, containing up to seven glucose residues. The new methods allow for selective color detection of fructose in a large excess of glucose and simultaneously determination of glucose. The fundamental problem of diminished optical detection of larger oligosaccharides is overcome using simple colorimetric agents. In addition, the first evidence that xanthenes form and serve as the active chromophores in resorcinarene solutions is presented. Meanwhile, the saccharide-induced optical signal transduction mechanism is investigated. A synthesis of resorcinarene derivatives, which have potential application in liposome stabilization, is also described.
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