Title page for ETD etd-07112011-161646


Type of Document Dissertation
Author Acharya, Jiba Raj
URN etd-07112011-161646
Title Preparation and Studies of Ratiometric Fluorescent Chemosensors Based on the Attenuation of Excitation Energy Transfer
Degree Doctor of Philosophy (Ph.D.)
Department Chemistry
Advisory Committee
Advisor Name Title
Nesterov, Evgueni. E. Committee Chair
Garno, Jayne Committee Member
Spivak, David A. Committee Member
Taylor, Carol M. Committee Member
Laws, Edwards Dean's Representative
Keywords
  • Sensors
  • Fluorescence
  • Oligomer
Date of Defense 2011-02-23
Availability unrestricted
Abstract
Molecular devices possessing pi-electron conjugated scaffold demonstrate unique capabilities as fluorescent chemosensors for the trace detection of analytes in a variety of environments. Important properties of these compounds such as charge transport and exciton migration, emission intensity etc. can be simply attenuated by external stimuli or analyte binding, leading to considerable changes in observable signals. The main goal of this Ph.D. dissertation was to study the possibility to control excitation energy migration in conjugated systems. Towards this goal, we designed surface-immobilized monodispersed oligo(p-phenylene ethynylene)s (OPEs) as a general basis for thin-film ratiometric fluorescent chemosensors. The sensor molecules have been functionalized with a specific analyte receptor at one end and a linkage for the covalent attachment to a glass surface at the opposite end. Upon surface immobilization these sensor molecules form a highly ordered monolayer with the receptors positioned at the monolayer surface. Analyte binding to the receptor causes attenuation of the HOMO-LUMO gap at the receptor terminus leading to the ratiometric change in fluorescent emission. The thin-film sensors for L-cysteine, pH and Zn2+ were prepared and studied in detail to uncover a number of unusual properties, thus demonstrating the potential of this platform as a universal foundation for designing a broad range of fluorescent ratiometric thin-film chemosensors.
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