Title page for ETD etd-07102009-101519

Type of Document Master's Thesis
Author Hollingsworth, Javoris
Author's Email Address jholl15@lsu.edu
URN etd-07102009-101519
Title A Study of the Self-Assembly of Water-Soluble Porphyrins in Aqueous Solution
Degree Master of Science (M.S.)
Department Chemistry
Advisory Committee
Advisor Name Title
Graca H. Vicente Committee Chair
Paul S. Russo Committee Co-Chair
David A. Spivak Committee Member
  • small angle x-ray scattering
  • analytical ultracentrifugation
  • porphyrin aggregation
Date of Defense 2009-06-24
Availability unrestricted
In nature, self-assembly processes of biologically active organic molecules often occur, resulting in formation of dimers and higher oligomers of various and sometimes complex structures. This natural occurrence of self-organization has been the subject of research, with the aim of understanding and possibly modulating the aggregation behavior of biological molecules. The meso-tetrakis(4-phosphonatophenyl) porphyrin, H2TPPP was synthesized, purified, and characterized. Its self-assembly was studied in aqueous solutions as a function of pH and time. The variations on the λmax and shape of the Soret band of this porphyrin in the absorption spectra when altering the pH indicated the pH dependency in the hierarchical self-assembly of H2TPPP in aqueous solution. The aggregation as a function of time was monitored via fluorescence spectroscopy, where the emission intensity decrease suggests self-quenching and aggregation. Small angle x-ray scattering experiments were conducted in an attempt to obtain structural information for the self-organized porphyrin complexes. Analytical ultracentrifugation techniques confirmed reported SAXS results and also revealed the self-associative behavior of the aggregates.
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