Title page for ETD etd-07022007-214620

Type of Document Master's Thesis
Author Tripathy, Sasmita
Author's Email Address stripa1@lsu.edu
URN etd-07022007-214620
Title Resistant Starch Does Not Reduce Body Fat in Rats Fed a High Fat Diet
Degree Master of Science (M.S.)
Department Human Ecology
Advisory Committee
Advisor Name Title
Michael Keenan Committee Chair
Richard Tulley Committee Member
Roy Martin Committee Member
  • high fat
  • proglucagon
  • gut signaling
  • pyy
  • body fat
Date of Defense 2007-06-27
Availability unrestricted
This study examined the effects of resistant starch in a high fat diet (28% of energy) on body weight, abdominal fat, cecal weight and pH, serum gut peptide YY (PYY) and gene expression for PYY and proglucagon in male Sprague Dawley rats. Three groups of rats (8wk) were fed one of the following diets for ten wks: energy control (EC; 3.7 kcal/g), resistant starch (RS; 3.7 kcal/g) and fiber control (FC; 2.9 kcal/g). Results were classified as significant when p<0.05. The consumption of RS resulted in significant increases in cecal weight (full and empty), serum PYY, gene expression for PYY and proglucagon in cecum and significant decrease in pH in cecal contents compared to the other groups. However, the disemboweled body weight and abdominal fat for RS were not lower compared to the EC. In our previous studies, we observed that RS in a low fat diet (18% of energy), produced similar gut signaling, as in the current study, but reduced disemboweled body weight and abdominal fat compared to EC. The reason for the unexpected results needs further study. Since high fat diets have been shown to alter brain response to other satiety signals (leptin), a high fat diet might affect neuronal responses to PYY and GLP-1 signaling from the gut caused by dietary RS.
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