Title page for ETD etd-06162005-142747

Type of Document Master's Thesis
Author Piattoly, Tavis Joseph
URN etd-06162005-142747
Title L-Glutamine Supplementation: Effects on Recovery from Exercise
Degree Master of Science (M.S.)
Department Kinesiology
Advisory Committee
Advisor Name Title
Michael Welsch Committee Chair
Arnold Nelson Committee Member
Robert Wood Committee Member
  • supplemenation
  • exercise
  • glutamine
Date of Defense 2005-05-17
Availability unrestricted
Clinical evidence supports the use for exogenous glutamine in the maintenance of muscle

mass and immune system function in critically ill patients. Relatively little research has

examined the benefits of glutamine for athletes engaged in heavy exercise

training, despite a possible link between overtraining and glutamine. PURPOSE: To

examine the influence of Glutamine on time to exhaustion and power after a

prolonged bout of exercise. METHODS: Twelve men (Age: 19 to 30y) involved in cycle

training were asked to participate in the study. All participants performed a

Symptom-Limited Graded Exercise Test (SL-GXT) using the Astrand Cycle protocol. On

a subsequent visit participants performed two Wingate tests on a cycle ergometer to

assess Peak Power, Mean Power, and Fatigue Index. The tests were separated by an

exhaustive bout of exercise at 70% of VO2R. Twenty-four hours later another Wingate

test was performed. Immediately after performing the last Wingate test, subjects were

randomized to: 1. Glutamine plus carbohydrate drink (0.3 grams/kg of body weight/ for 6

days) or 2) Placebo (Carbohydrate drink). After 6 days the Wingate and exhaustive bout

of exercise were repeated in each individual. RESULTS: There were no group

differences in VO2peak (Glu: 44.53+8.75; Pla: 43.83+5.26 ml/kg/min), PP (Glu:

717.71+118.90; Pla: 593.66+117.08), TR (Glu: 38.50+2.26; Pla: 35.50+5.65) and time to

exhaustion (Glu: 46.33+10.80; Pla: 41.90+3.82 ml/kg/min) before supplementation. Both

groups showed a significant drop in PP (-27%, p=0.001), and TR (-22%, p=0.001) after

the exhaustive exercise bout. Incomplete recovery was noted at 24h PP (-17%, p=0.03 vs.

baseline), and TR (-13%, p=0.09 vs baseline). Following supplementation TE improved

by 3.16+0.75min in the Glu group compared to no change in the Pla (p=0.001). Lastly,

the Glu group had similar PP prior to each exhaustive bout of exercise, the PP in the Pla

group was still significantly lower after 6 days. CONCLUSION: Participants in the Glu

group increased time to exhaustion following 6 days of supplementation, and appeared to

recover from exhaustive exercise earlier than the Pla group.

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