Title page for ETD etd-05312006-163518


Type of Document Master's Thesis
Author Lestage, Robert B.
Author's Email Address rlesta1@lsu.edu
URN etd-05312006-163518
Title Examination of Blood Flow Using Vasoconstrictor and Vasodilator Stimuli: Stability and Reproducibility
Degree Master of Science (M.S.)
Department Kinesiology
Advisory Committee
Advisor Name Title
Michael Welsch Committee Chair
Arnold G. Nelson Committee Member
Maria Kosma Committee Member
Keywords
  • plethysmography
  • blood flow distribution
Date of Defense 2006-05-17
Availability unrestricted
Abstract
Blood flow distribution relies on the vasculature’s ability to vasodilate and

vasoconstrict throughout the body. Most previous research has focused on only one

of these abilities, either vasodilation or vasoconstriction. For example, Thijssen et al.

(2005) focused their research on vasodilation by studying reactive hyperemia, while

Kinuyoshi et al. (2003) studied the possible vasoconstriction effect with increasing

muscle sympathetic nerve activity. The purpose of this study was to assess vascular

function using a variety of stimuli to potentially learn more about overall vascular

health, while determining the stability and reliability of blood flow measurements

using strain gauge plethysmography. Measures of vascular function were examined

in 12 individuals [age=21±1 yrs]. Right lower leg resting arterial inflow, post

occlusion reactive hyperemia, dynamic exercise blood flow, and blood flow following

a cold stimulus were assessed on two separate occasions. The average resting arterial

inflow was 2.27 ± 1.06 ml/100ml/min, reactive hyperemic blood flow was 19.42 ±

6.37 ml/100ml/min, exercise blood flow was 27.37 ± 14.95 ml/100ml/min, and blood

flow following a cold stimulus was 1.53 ± 0.89 ml/100ml/min. A rather unique

finding was the associations between the stimuli blood flow responses, by which

those with the greatest reactive hyperemia blood flow responses also exhibited the

greatest exercise blood flows and greatest drop in blood flow following the cold

stimulus. In conclusion, the pattern of the blood flow responses and the correlations

among the measurements, in addition to being stable and reliable, provide us with a

greater understanding of the blood flow distribution properties of the vasculature.

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