Title page for ETD etd-04152004-134854

Type of Document Master's Thesis
Author Bahadir, Zeki
Author's Email Address zbahad1@lsu.edu, mdzeki@hotmail.com
URN etd-04152004-134854
Title Influence of Venous Emptying on Reactive Hyperemic Blood Flow
Degree Master of Science (M.S.)
Department Kinesiology
Advisory Committee
Advisor Name Title
Michael Welsch Committee Chair
Arnold Nelson Committee Member
Robert Wood Committee Member
  • reactive hyperemic blood flow
  • venous outflow
  • venous emptying
  • arterial inflow
  • venous capacitance
Date of Defense 2004-04-02
Availability unrestricted
Recent work by Tschakovsky & Hughson (Am J Physiol Heart Circ Physiol 279: H1007, 2000) indicates that venous emptying serves as a stimulus for vasodilation. This suggests the importance of recognizing the potential influence of venous volume on reactive hyperemic blood flow (RHBF) following occlusion. Purpose: To examine the influence of venous emptying on RHBF. Methods: Non-dominant forearm in-flow, venous capacitance and outflow were examined in 21 individuals [age=232.27y]. Forearm arterial inflow, venous capacitance, and outflow were obtained two times using strain gauge plethysmography. Forearm blood inflow was estimated at rest and following 5 min of upper arm occlusion. Forearm venous capacitance and outflow were obtained following 5 min of upper arm venous occlusion pressure at 7 mmHg below diastolic blood pressure. Prior to the second measure the arm was passively elevated for 2 minutes. Immediately before returning the arm to its original position the upper arm cuff was again inflated to 240mmHg. Subsequently, RHBF and venous measures were obtained. Results: Average resting in-flow was 2.841.22 ml/100ml/min. RHBF was significantly greater following venous emptying (Before: 18.153.80; After: 23.705.93 ml/100ml/min, p=0.0001). Venous capacitance was also greater (Before: 1.960.82; After: 2.940.82 %, p=0.0001), whereas venous outflow (Before: 37.0610.50; After: 39.0010.72 ml/100ml/min, p=0.17) remained unaffected after venous emptying. Summary: Venous emptying prior to upper arm occlusion results in a significant greater RHBF response and venous capacitance. A potential explanation for the observation is a decrease in the pressure gradient across the tissue bed and/or withdrawal of the venoarteriolar reflex constriction.
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