Title page for ETD etd-04122010-092452


Type of Document Master's Thesis
Author Gudehus, Timm
URN etd-04122010-092452
Title Applicability and Integration of Plasma Sprayed Hydroxyapatite Coated AO Cortical Bone Screws in Equine Bone
Degree Master of Science (M.S.)
Department Veterinary Clinical Sciences
Advisory Committee
Advisor Name Title
Sod, Gary A., DVM, PhD Committee Chair
Burba, Daniel J. Committee Member
Mitchell, Colin F. Committee Member
Keywords
  • Hydroxyapatite
  • Equine bone
  • osseointegration
Date of Defense 2010-03-24
Availability unrestricted
Abstract
To compare insertion temperatures and torques of Hydroxyapatite (HA) coated and uncoated 5.5 mm AO cortical screws in equine third metatarsal bones (MTIII) in vitro, and to compare insertion and extraction torques of HA coated and uncoated screws after 4, 8, 12 and 16 weeks of healing in equine third metacarpal bones (MCIII) in vivo.

No significant temperature differences were recorded in cadaveric bones for AO and HA coated screws. Insertion torques were significantly higher for HA coated implants compared to uncoated screws. In vivo, the AO screws lost 50% of their initial stability within 4 weeks of healing and failed to gain stability over the next 12 weeks. The HA screws maintained stability (at 4 weeks), and roughly doubled (at 8 weeks) and tripled (at 12 weeks) their insertional torques over time.

HA coated screws can safely be inserted in equine cortical bone. AO cortical stainless steel screws fail to maintain stability in equine cortical bone. The addition of HA coating to the screws enables active osseointegration over 3 months of healing, as indicated by significantly higher extractional torques after 8, 12 and 16 weeks respectively.

Screw failure can occur under acute load and cyclic fatigue indicating the need for improved stability in the equine patient. HA coating, leading to active osseointegration, is commonly used in human implants for this purpose. Varying results in equine models led to guarded acceptance of implant coatings amongst equine surgeons. Our results support the osseointegrative properties of HA coated screws in horses.

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