Title page for ETD etd-04122005-204341

Type of Document Dissertation
Author Uzelac, Sarah Mathews
Author's Email Address suzela1@lsu.edu
URN etd-04122005-204341
Title Serotonin and Stress Responding in Animals: Role of 5-HT2A/C Receptors in the Central and Peripheral Nervous Systems
Degree Doctor of Philosophy (Ph.D.)
Department Psychology
Advisory Committee
Advisor Name Title
Mike Hawkins Committee Chair
Alan Baumeister Committee Member
Jason Hicks Committee Member
Paula Geiselman Committee Member
Doo-Youn Cho Dean's Representative
  • 5-HT
  • tail pinch
  • DOI
  • open field
  • ketanserin
  • anxiety
Date of Defense 2005-03-30
Availability unrestricted
Behavioral responses to stressors can be influenced in different ways by both serotonin (5-HT) agonists and antagonists. Further study, of both different stressors as well as different 5-HT agents, is needed to clarify the place of 5-HT in stress responding. To date, no published report has investigated the influence of centrally and/or peripherally administered 5-HT2A/C agonist DOI or the 5-HT2A/C antagonist ketanserin on behaviors evoked by tail pinch or open field stressors. Five separate, related experiments were conducted to investigate this influence. It was hypothesized that that peripherally (Experiment 1), centrally (Experiment 2), and centrally + peripherally (Experiment 3) injected DOI would reduce stress responding to tail pinch and open field stressors, and that peripheral injection of ketanserin (Experiment 4) would increase behavioral responding to stress when injected alone, as well as reverse the reduction in behavioral responding from injection of DOI (Experiment 5). The results strongly supported the hypotheses. Administration of DOI resulted in significantly decreased behavioral responding to tail pinch stress in all five experiments, regardless of route of administration. Concomitant peripheral administration of KET and DOI resulted in a reversal of the decrease in stress-evoked behaviors seen with administration of DOI alone. This is the first report of the influence of centrally and peripherally administered DOI on behaviors evoked by tail pinch or open field stress, and the reversal of that influence by the 5-HT2A/C antagonist ketanserin. Future investigations should be designed to study whether the effects observed in the current report are centrally or peripherally mediated.
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