Title page for ETD etd-0410103-122444


Type of Document Master's Thesis
Author Fulmer, Preston A
URN etd-0410103-122444
Title Susceptibility of Bacillus anthracis to Gamma and Cherry Bacteriophage
Degree Master of Science (M.S.)
Department Veterinary Microbiology and Parasitology (Veterinary Medical Sciences)
Advisory Committee
Advisor Name Title
Martin Hugh-Jones Committee Chair
James Miller Committee Member
Richard Corstvet Committee Member
Keywords
  • bacteriophage
  • bacillus anthracis
  • cherry phage
  • gamma phage
  • anthrax
Date of Defense 2003-03-14
Availability unrestricted
Abstract
Bacillus anthracis is a bacterium that causes severe disease mainly in ruminants, but can affect any mammal, including humans. A popular method for the detection of this organism is susceptibility of the bacterial isolate to g bacteriophage. However, to date no study on the resistance of a wide variety of B. anthracis isolates has been conducted. The following study examines the rate of resistance of a wide range of B. anthracis isolates to g phage as well as another phage specific for B. anthracis known as Cherry phage. We also compared susceptibility to phage with another detection method, susceptibility to penicillin, to determine any association between the two. The origin of the resistant isolates was examined to determine associations between resistance and isolate origin. Finally, the gross structure and resistant rates of the two phages were compared to determine any relation between the two viruses. We found that B. anthracis showed 20% resistance to g phage, which we propose is too high to continue its use as a reliable diagnostic tool. No association was found between resistance to penicillin and resistance to phage. No association was found between isolate origin and resistance. No conclusions could be drawn as to the relationship between the two phages.
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