Title page for ETD etd-04092008-140338


Type of Document Dissertation
Author Easson, Michael William
URN etd-04092008-140338
Title Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy
Degree Doctor of Philosophy (Ph.D.)
Department Chemistry
Advisory Committee
Advisor Name Title
M. Graca H. Vicente Committee Chair
Andrew Maverick Committee Member
Kevin M. Smith Committee Member
William Daly Committee Member
Fareed Aboul-ela Dean's Representative
Keywords
  • cancer therapy
  • porphyrin
  • carborane
Date of Defense 2008-04-04
Availability unrestricted
Abstract
Chapter 1 contains an introduction to porphyrins and carboranylporphyrins, including their physical properties, history, methods of synthesis, medicinal applications, and an overview of recently published compounds. Chapter 2 contains the total synthesis of a series of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in boron neutron capture therapy (BNCT), including characterization by proton nuclear magnetic resonance spectroscopy, matrix-assisted time-of-flight mass spectroscopy, high resolution mass spectroscopy, UV-Vis spectrophotometry, X-ray crystallography, and melting point apparatus. Chapter 3 contains synthetic methods which were investigated as alternate routes to porphyrin synthesis and functionalization. Chapter 4 presents the in vitro biological evaluation of trimethylamine- and phosphonate-substituted carboranylporphyrins.
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