Type of Document	Dissertation
Author	Sherriff, Mohamed G
URN	etd-03112005-165301
Title	The Stereoselective Synthesis of the Butyrolactone-Bridged [8-5-5] Tricyclic Ring Systems of (+/-)-Asteriscanolide Via the Titanium-Mediated Hetero-Pauson-Khand Reaction
Degree	Doctor of Philosophy (Ph.D.)
Department	Chemistry
Advisory Committee	Advisor Name Title Graca Vicente Committee Chair David Spivak Committee Member Robert Strongin Committee Member William E. Crowe Committee Member Vincent Wilson Dean's Representative
Keywords	Hetero-Pauson-Khand titanium ring tricyclic butyrolactone synthesis stereoselective
Date of Defense	2004-12-09
Availability	unrestricted
Abstract The stereoselective construction of the tricyclic ring system of asteriscanolide from cyclooctadiene has been achieved. The synthesis involves two main steps; the synthesis of the aldehyde precursor(5)and the titanium-mediated cabocyclization of 5 to make the three rings of 43 stereoselectively.
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